Yes, just create a weblog where the frontpage template has a subweblog which only displays one entry. Inside the subweblog tag (that you are using in the frontpage template) you can use all/most tags that you normally use in the entrypage template - like [[commcount]], [[trackcount]], [[comments]], [[trackbacks]] and [[commentform]].
NB! This requires using PivotX revision 2561 or newer. It will be part of PivotX 2.1.0 beta5/RC or you can grab PivotX Latest from http://pivotx.net/files/unstable-development/
PS! If you are using HashCash, you need to replace [[self]] with [[link hrefonly=1]] in templates/_sub_commentform.html.